Business
NEURO-PHARMACOGNOSIA : IS IT NATURE’S ANSWER FOR NEUROPATHY?

Neuropathy literally means diseased nerves. There are a number of different reasons why people develop neuropathy. Neuropathy is quite commonly associated with diabetes, vitamin deficiencies, nerve inflammation, and toxins that poison the nerves. We have discussed many of the conditions that cause nerve disease in patients in other articles. Patients suffering from the signs and symptoms of neuropathy experience pain, burning, numbness, and other strange sensations known as paresthesias, which usually start in the feet and spread to the rest of the body. Regardless of the cause of the neuropathy, the pain and other symptoms can be debilitating and incapacitating.
The nervous system in higher animals like humans is a highly complex collection of specialized cells known as neurons. Neurons have several unique features, including a wire-like extension known as an axon. The axon works much like an electrical wire, carrying coded electrical signals known as nerve impulses throughout the body. Just like a copper wire, the nerve axon has an insulation known as myelin. Unlike a copper wire, a nerve cell and its wire-like axon are living tissue. The neuron contains all of the cellular machinery necessary to produce energy, sustain itself, and generate energy to support its function of sending and receiving electrical signals. Blüten kaufen Each neuron is an electrochemical marvel and essentially a living battery. This amazing communication network occurs at the microscopic level and consumes incredible amounts of energy to function properly.
The myelin insulation that surrounds the nerve axon is also a living tissue, and the nerve cell and its myelin cell partners are closely arranged to sustain and support each other.
The nervous system typically does a remarkable job of sending and receiving information from different parts of the body, acting both as a sensory system to monitor what’s going on in the body and as an effector system, driving necessary changes in the body based on the input from the sensors.
Because of its complexity, the nervous system and its supporting myelin cells are vulnerable to the slightest perturbation of metabolism. The axons are like a microscopic spider web, yet they travel great distances in the body. They can be very easily dysregulated by trauma or compression.
Think of the nervous system as a living, sensitive, and vulnerable communications network that requires inordinate amounts of energy to function and maintain properly. It’s no wonder the nervous system is susceptible to injury, disease, metabolic abnormalities, immune problems, and many other ailments that can make it ill and fail.
Peripheral nervous system dysfunction is common, and when this occurs, people develop the cardinal symptoms of polyneuropathy.
Despite the fact that polyneuropathy is one of the most common peripheral nervous system disorders, there are few FDA-approved drugs to treat it. Many patients who try traditional prescription medications to relieve their neuropathy symptoms are disappointed with the results.
Too often, newer drugs in the research pipeline appear promising, but fail because of undesirable side effects. Research and data from failed drug development experiments can sometimes be applied to herbal medicine, where natural substances work in ways similar to artificial chemicals, but with less severe side effects. The scientific study of natural substances that can mimic man-made drugs is called pharmacognosy . When this knowledge is applied to the nervous system, we call it neuropharmacognosy . This can be translated as the theory of the pharmacology of natural substances that can influence the functioning of the nervous system. There are a number of natural substances that can mimic the pharmacology of drugs used to treat neuropathy. We’ve discussed them in other articles, but we’ll go through them together here.
Based on experimental data on nerve function and disease, a number of broad classes of chemicals have theoretical utility in alleviating symptoms of neuropathy.
When nerves get sick, it appears that increasing a chemical known as GABA can calm irritated and inflamed nerves and provide relief for people struggling with the symptoms of neuropathy. You can think of GABA as a brake pedal, slowing down the symptoms of neuropathy. There is research to suggest that the herbs valerian root and lemon balm may increase GABA, which applies the body’s natural brakes on nerve pain. Valerian root can block an enzyme known as GABA-T, which breaks down and neutralizes GABA in the nervous system. By blocking the breakdown of GABA, valerian root can prolong the braking effect of GABA on the nerve and slow down the symptoms of neuropathy. Lemon balm appears to enhance the effects of GABA in a slightly different way. Rather than blocking the breakdown of GABA, lemon balm can stimulate an enzyme called GAD, which is responsible for building GABA. The braking effect of GABA on the diseased nerve is thus supported by the increased production of this neurotransmitter
If GABA acts like the body’s brakes on an out-of-control nervous system, glutamate is the nerve’s accelerator. Studies suggest that injured nerves become hypersensitive because glutamate is released after the nervous system is irritated. This has the effect of sensitizing the nerve and contributing to the signs and symptoms of neuropathy. There are two potentially important herbs that can block the effects of glutamate on the nervous system in neuropathy. The first is theanine , a protein derived from green tea. Theanine is believed to act as a glutamate analogue. This means that theanine is processed by the body like glutamate, but lacks the nerve-stimulating effects of glutamate. Think of theanine as an empty sphere that has the net effect of reducing the effects of glutamate. The other herb that can reduce the excitatory effects of glutamate is magnolia bark. Magnolia bark is believed to bind to and block a specific glutamate receptor. This suggests that magnolia bark is a specific antagonist of glutamate and may be a more specific way to take your foot off the accelerator in nerves damaged by neuropathy.
Consistent with our auto-analogy, if GABA is the nerve brake in neuropathy and glutamate acts like the gas pedal, a third chemical known as glycine could be considered the transmission. Glycine slows down the nervous system. Remember to put the nerve in low gear. Glycine downshifts the nerve directly in neuropathy, thus slowing and inhibiting the painful transmission of nerve signals, but it can also compete indirectly with glutamate. The mechanism by which glycine might provide relief to patients suffering from neuropathy is a little less straightforward. If a patient took a large dose of glycine, the nerves would slow down. However, this effect would not last long, since glycine is transported away from the nerve in the nervous system by a so-called glycine transporter. The glycine transporter has the net effect of getting rid of glycine, which effectively gets the nervous system back into high gear. This glycine transporter system is so effective that it makes glycine impractical as a treatment for neuropathy. Because of the glycine transporter, the nerve simply cannot keep enough glycine in the nerve to meaningfully slow down the function of a hypersensitive nerve. However, there are substances that can inhibit the glycine transporter , and this appears to be a promising avenue to improve the suppression of nerve hyperexcitability as seen in neuropathy. The herb prickly ash bark appears to be a major glycine transporter inhibitor. Prickly Ash has long been used to relieve pain. Likewise, the naturally occurring compound sarcosine is a known inhibitor of the glycine transporter. Both of these naturally occurring substances appear to be candidates for relieving the signs and symptoms of neuropathy.
Another avenue that can be used to alleviate neuropathy is through the endogenous cannabinoid receptor system. This system is activated by marijuana and is thought to suppress pain at the higher levels of the nervous system. The receptors of the endogenous cannabinoid system can be activated by certain breakdown products of fatty acids in the nervous system for pain relief without inducing the “high” and side effects associated with marijuana drug use . Substances that block the enzyme fatty acid amide hydrolase, or FAAH, appear to activate the endogenous cannabinoid system and are currently being studied for the treatment of neuropathic pain. There appear to be naturally occurring FAAH inhibitors in red clover and the herb MACA. This suggests that through their potential to modulate the activity of the enzyme FAAH, these herbs may be able to activate the endogenous cannabinoid system and relieve neuropathic pain.
Finally, with particular reference to the neuropathy associated with diabetes, the protein kinase – C or PKC enzyme and its relationship to T-type calcium channels may be therapeutic targets. It appears that elevated blood sugar unregulates PKC in diabetic nerves. PKC appears to drive specific calcium channels in diabetic nerves known as T-type calcium channels. These changes are thought to drive hypersensitivity and excitability, at least in nerves affected by diabetic neuropathy.
chelidonium Majus is an herbal remedy that can modulate PKC. The alkaloid chelerythrine found in this herb is a potent protein kinase C antagonist. This suggests a potential benefit of this herb in polyneuropathy . While it is generally safe, some reports of liver toxicity have been linked to chelidonium Majus appear in the medical literature.
Picrorhiza Kurroa is an herb that contains phytochemicals apocynin . At least one study suggests that apocynin prevents or significantly reduces the upregulation of Cav3.1 and Cav3.2 T-type calcium channels. This suggests that Picrorhiza Kurroa may be able to downregulate the overexpression of Cav3.2 T-type calcium channels, which are thought to contribute to nerve hyperexcitability seen in diabetic neuropathy.
A final note and warning about using internet information to treat a medical problem. Do not do it! The use of this article is intended solely for patients to discuss the information contained with their licensed healthcare provider. While herbal treatments are generally safe, they can have unwanted or unpredictable side effects. Only a licensed physician who is familiar with your specific medical condition can diagnose you with certainty and advise you on the treatment of your particular condition. Always consult and inform your doctor before adding or changing your treatment regimen.
dr Kukurin is a board certified chiropractic neurologist with a certification in acupuncture. He has over 25 years of experience treating neurological disorders using alternative medicine techniques. He has presented the results of his methods at conferences in Johns Hopkins. His patients’ findings have been published in journals listed in the National Library of Medicine. dr Kukurin has postgraduate medical training from Harvard Medical School, Johns Hopkins, the Mayo Clinic and the Russian People’s Friendship Medical School. dr Kukurin completed a nine-month postgraduate course in Advanced Practice at the National University of Health Sciences. The course covered the pharmacology of commonly prescribed drugs, pharmacognosy, which is the study of the pharmacology of natural substances, herbal medicine and toxicology. For more information about the conditions he treats, these treatments , and the results his patients have achieved, visit his website.
Business
‘The Whole Thing Seems Insane: New Documents on Fox and the Election

As news networks projected Joseph R. Biden Jr. as the next president in November 2020, Fox News hosts Tucker Carlson, Sean Hannity, and Laura Ingraham were unsure what to say on air. Ms. Ingraham texted her colleagues, asking what they would do the following night. Mr. Carlson responded that he planned to feature Dominion Voting Systems, a little-known voting technology company that had become a target of Trump supporters who suspected the election had been rigged.
Mr. Carlson admitted feeling uneasy about the conspiracy theories surrounding Dominion’s purported role in a fictitious plot to siphon away votes from President Donald J. Trump. He wrote that the whole thing seemed insane to him, and Sidney Powell, a legal adviser to the Trump campaign, was making everyone paranoid and crazy, including him. Text messages like these, released as part of Dominion’s $1.6 billion defamation lawsuit against Fox News, offer some of the clearest evidence yet about the misgivings that many inside the network expressed to one another, despite telling their millions of viewers a different story of fraud and malfeasance at the polls.
Some Fox hosts and guests have continued to air claims about widespread election fraud and advance a revisionist account of the Capitol riot on January 6, 2021. Mr. Carlson, in particular, has evolved from a skeptic to an election denier, as seen in the newly disclosed messages. This week, he broadcast selectively edited footage, given to him by Speaker Kevin McCarthy, that tried to recast the attack as little more than an “orderly and meek” procession of curious sightseers who were rightfully upset with how the election had been conducted.
Despite ridiculing claims about a plot to steal the election as “shockingly reckless” and “absurd” in his November 2020 text messages, Mr. Carlson continued to give credence to lies about widespread voter fraud this week. He said on his Monday program that the protesters were angry and believed that the election they had just voted in had been unfairly conducted, and they were right.
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Rupert Murdoch: The conservative media mogul acknowledged in a deposition in a $1.6 billion defamation lawsuit that several Fox News hosts promoted the false narrative that the 2020 election was stolen.
Dropping ‘Dilbert’: Hundreds of newspapers across the country will stop running the comic strip after its creator, Scott Adams, said that Black people were “a hate group.”
Carlos Watson: The founder of the troubled digital start-up Ozy Media was arrested on fraud charges, punctuating one of the more precipitous falls in the annals of online journalism.
He added, without providing any specifics: “In retrospect, it is clear the 2020 election was a grave betrayal of American democracy. Given the facts that have since emerged about that election, no honest person can deny it.”
“With regard to the presentation on Fox News last night, I want to associate myself entirely with the opinion of the chief of the Capitol Police about what happened on Jan. 6,” Mr. McConnell said. Senator Mitt Romney of Utah, the Republican nominee for president in 2012, called Mr. Carlson’s broadcast “dangerous and disgusting.”
A Fox News spokeswoman said on Tuesday that Dominion had used “distortions and misinformation” in its recent filings by misattributing quotes and leaving out context to smear the network.
“We already know they will say and do anything to try to win this case, but to twist and even misattribute quotes to the highest levels of our company is truly beyond the pale,” the spokeswoman said.
Some of Mr. Carlson’s private remarks about Mr. Trump are difficult to square with the praise he has lavished on the former president publicly. At times, the host and his producers were gleeful about what a news cycle without Mr. Trump would look like. And they cheerfully predicted his waning power as a political force.
“We are very, very close to being able to ignore Trump most nights,” Mr. Carlson wrote to members of his staff on Jan. 4, 2021. “I truly can’t wait.”
One producer replied, “I want nothing more.”
Then Mr. Carlson responded, “I hate him passionately.”
The new documents show how Rupert Murdoch, chairman of Fox Corp, was also harshly critical of Mr. Trump — to the point of being disdainful at times. Mr. Murdoch said during his deposition in the Dominion lawsuit that he believed the former president was a sore loser.
And asked whether he had ever believed that there was “massive fraud” in the 2020 election, Mr. Murdoch replied unequivocally.
“No. I have never even studied it,” he said.
At one point, according to the full text of an email made public on Tuesday, Mr. Murdoch asked the chief executive of Fox News Media, Suzanne Scott, whether some hosts had been too willing to accept false accusations of fraud. Mr. Murdoch complained on Jan. 21, 2021, that Fox was “still getting mud thrown at us!” for inflaming the rhetoric that helped spur the Jan. 6 assault.
Then Mr. Murdoch conceded, referring to Mr. Hannity and Ms. Ingraham, “Maybe Sean and Laura went too far.”
The messages also show how Fox hosts like Mr. Carlson and Ms. Ingraham were furious at their colleagues on the Fox News decision desk, the group that calls elections for the network, whose early prediction that Mr. Biden would win Arizona angered Mr. Trump and his supporters.
Ms. Ingraham said the work of the decision desk was an inside job, intended to sabotage conservative hosts like her. “We are all officially working for an organization that hates us,” she fumed.
Dominion’s lawsuit poses a serious threat to Fox’s business and reputation. Although libel cases against media organizations are historically hard to win, the recent documents show the mounting evidence Dominion has so far gathered to persuade a jury of its central claim: that Fox knew the election fraud claims were false but recklessly promoted them anyway.
But it is not a full picture. Fox lawyers redacted the documents extensively, leaving much of what people said to one another under seal. The New York Times and several other media outlets are challenging the legality of those redactions.
Lawyers for Fox say the network was merely reporting on newsworthy events, covered by the First Amendment, by airing Mr. Trump’s allegations, and have provided some examples where hosts pushed back on the claims or added a caveat that evidence of the fraud had not yet been produced.
They have also argued that Dominion’s business wasn’t meaningfully hurt and that the $1.6 billion damages claim is not justified. A Fox News spokeswoman pointed to an email in the latest cache of documents sent by John Poulos, the chief executive of Dominion on Dec. 4, 2020. Mr. Poulos, responding to another executive’s concerns that Dominion was not speaking out enough publicly against the false claims, said: “No customer cares about the media. It’s just more words from their perspective.”
The revelations from the documents have reverberated among some conservatives who have long mistrusted Fox News, though conservative media has largely stayed far away from reporting on the specifics of the case. Mr. Trump has taken aim at Mr. Murdoch on multiple occasions in the past week on his social app, Truth Social, labeling him and his supporters “MAGA Hating Globalist RINOs.” (RINO stands for “Republican in name only.”)
In a post on March 2, Mr. Trump said: “Rupert Murdoch should apologize to his viewers and readers for his ridiculous defense of the 2020 Presidential election.” He added, “He should also apologize to those anchors who got it right, and fire the ones who got it wrong, or were afraid to speak up (of which there were many!)”
The sanitizing of the events of Jan. 6 on shows like Mr. Carlson’s for the last two years seems all the more glaring given his words on Jan. 7, 2021. The new documents contain a text message chain that the host had with his producers that morning.
When Mr. Carlson again predicts that Mr. Trump’s clout will fade as he “becomes incalculably less powerful” out of office, one of his producers frets that the last weeks of Mr. Trump’s presidency could bring even more chaos and danger.
“The Trump anger spiral is vicious,” the producer tells his boss.
“That’s for sure,” Mr. Carlson responds.
“Deadly,” the host adds. “We’ve got two weeks left. We can do this.”
Business
THE BEST BOXING GLOVES MONEY CAN BUY

If you take up the sport of boxing, you should have high-quality gear. This means owning some excellent gloves. With this in mind and from looking over other articles (not written by professional boxers, mind you), this article is organized as follows: I’ll give my best recommendations for the different situations and scenarios you encounter in a boxing gym. My suggestions are broken down by glove style, purpose or glove, and price.
Anyone in the boxing gym needs a high-quality pair of boxing gloves. Or, at the very least, you have to ensure that you have the best gloves they can afford. It doesn’t matter whether you’re:
- An amateur boxer
- A professional boxer
- Using boxing workouts at home or in the gym to get in shape
- Just trying out sweet science as a hobby
- This list is for you. More importantly, this list is timeless.
Your boxing gloves should fit you perfectly and be cozy. When wearing gloves, your fingertips should be able to brush the top of the glove. They shouldn’t do so snugly that a fist is challenging to form.
You can punch more confidently if you feel nice and at ease after wearing gloves.
The question now emerges: Why do you need boxing gloves?
A thicker glove will protect your hand better and slow your punching motion. To protect yourself and your sparring partner, use gloves with greater cushioning.
If you’re exercising with big bags, you’ll need thickly padded gloves, which provide excellent hand and knuckle protection and wrist support. Fighting or competition gloves have less padding than other types of gloves.
Signs That Your Boxing Gloves Fit Wrong
- The first time you wear them, they feel tight. Boxing might cause your hands to swell a little. Sweating and exertion are natural causes of that. It’s possible that your boxing gloves will become too constricting during training if they already feel snug when you first put them on.
- You experience tingling or numbness in your hands while boxing.Hands and wrists can be impeded by too tight boxing gloves. The wrong gloves might be causing you tingling or numbness when you wrap your hands during training.
- If your boxing gloves fall off when you train, they may slide off.A wrist closure problem is one that can result in problems with your boxing gloves slipping while you train – or you might be at risk of the gloves falling off entirely – if you notice the gloves shifting too much.
- You feel cramped in your fingers. There is too much space between them. If your fingers feel crushed against the top of your boxing gloves, they’re not the right fit. But if you can’t reach the top of your boxing gloves with your fingers, they’re not suitable for you.
- You’re thinking about how your boxing gloves fit when you train. Boxing gloves are designed to support boxers while they train and compete. If you can’t focus on your training because your gloves feel uncomfortable or because they are shifting on your hands and distracting you, then they’re not suitable gloves for you.
This article will show you how to select the correct gloves for sparring, training, or attacking a heavy bag with a heavy bag sparring glove. This way, you can avoid buying a cheap boxing glove even if you do not like my recommendations. I would love for you to purchase through my link here if my recommendations helped you decide.
Business
The Stock Market Faces A Crucial Test This Week: 3 Questions That Could Decide Rally’s Fate

There will be no rest for investors this week as they await a marquee report on the state of the U.S. labor market, along with biannual Congressional testimony from Federal Reserve Chairman Jerome Powell.
Further complicating things, investors will also be watching to see how stocks react to more attractive risk-free returns in the bond market after the yield on the 10-year Treasury note last week temporarily topped the 4% threshold, with many expecting it to climb even further.
Was Januarjobjob’s number a ‘fluke’?
On the economic data front, the most important question that investors will be looking to answer is whether January’s huge job gains continued in February. The U.S. economy added 517,000 jobs in January, according to the Labor Department, far outstripping expectations and setting in motion a market rethink on just how high the Federal Reserve will take interest rates in its effort to bring down inflation.
Since then, weekly jobless benefit claims have continued to show few Americans filing for unemployment benefits, fueling expectations that another blockbuster gain in jobs could be due in the data for February next Friday, which in turn could force the Federal Reserve to resort to even more aggressive interest rate hikes, according to Steve Sosnick, chief strategist at Interactive Brokers, during a phone call with MarketWatch.
“Will it turn out that the number we got last month was a fluke? Or is this part of a new trend?” Sosnick said.
What will Powell say?
Investors haven’t heard from Powell since he participated in a Q&A at the Economic Club of Washington on Feb. 7.
During his back-and-forth with private-equity billionaire David Rubenstein, Powell reiterated that signs of disinflation are emerging, although he acknowledged the journey back to the Fed’s 2% target would likely be “bumpy.”
Since then, a run of hotter-than-expected inflation reports showed that a streak of waning price pressures might be coming to an end.
The cost of living rose 0.5% in January, the biggest increase in three months, according to the consumer-price index released Feb. 14. The annual rate of inflation, meanwhile, slowed again to 6.4% from 6.5%, but economists had expected an even larger decline. The January producer-price index and the core personal consumption expenditure index, the Fed’s favored inflation measure, also came in hotter than expected.
As a result, investors will be listening closely to Powell to see what the Fed chair has to say about the central bank’s efforts to crush inflation when he heads to Capitol Hill on Tuesday for testimony before the Senate Banking Committee, followed by testimony before the House Financial Services Committee a day later.
“If the Fed truly is data dependent, the latest inflation data hasn’t been at all what the Fed wants to see. So how will Powell dance around that?” Sosnick told MarketWatch, in a phone interview.
How will stocks respond to higher yields?
On top of the economic data and commentary from Powell, investors will also be watching to see how higher bond yields will impact equities.
The fact that investors can now earn a yield north of 5% by simply buying six-month Treasury bills means stocks are now facing major competition from a far less risky asset class, according to Callie Cox, U.S. investment analyst at eToro.
What’s more, many on Wall Street expect bond yields to continue to climb, potentially adding to the pressure facing U.S. equity benchmarks like the S&P 500 index SPX, +1.61%, Nasdaq Composite COMP, +1.97% and Dow Jones Industrial Average DJIA, +1.17%.
“We expect the adjustment in rates is not over,” according to a team of economists at Mizuho Securities.
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