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NEURO-PHARMACOGNOSIA : IS IT NATURE’S ANSWER FOR NEUROPATHY?

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Neuropathy literally means diseased nerves. There are a number of different reasons why people develop neuropathy. Neuropathy is quite commonly associated with diabetes, vitamin deficiencies, nerve inflammation, and toxins that poison the nerves. We have discussed many of the conditions that cause nerve disease in patients in other articles. Patients suffering from the signs and symptoms of neuropathy experience pain, burning, numbness, and other strange sensations known as paresthesias, which usually start in the feet and spread to the rest of the body. Regardless of the cause of the neuropathy, the pain and other symptoms can be debilitating and incapacitating.

The nervous system in higher animals like humans is a highly complex collection of specialized cells known as neurons. Neurons have several unique features, including a wire-like extension known as an axon. The axon works much like an electrical wire, carrying coded electrical signals known as nerve impulses throughout the body. Just like a copper wire, the nerve axon has an insulation known as myelin. Unlike a copper wire, a nerve cell and its wire-like axon are living tissue. The neuron contains all of the cellular machinery necessary to produce energy, sustain itself, and generate energy to support its function of sending and receiving electrical signals. Blüten kaufen Each neuron is an electrochemical marvel and essentially a living battery. This amazing communication network occurs at the microscopic level and consumes incredible amounts of energy to function properly.

The myelin insulation that surrounds the nerve axon is also a living tissue, and the nerve cell and its myelin cell partners are closely arranged to sustain and support each other.

The nervous system typically does a remarkable job of sending and receiving information from different parts of the body, acting both as a sensory system to monitor what’s going on in the body and as an effector system, driving necessary changes in the body based on the input from the sensors.

Because of its complexity, the nervous system and its supporting myelin cells are vulnerable to the slightest perturbation of metabolism. The axons are like a microscopic spider web, yet they travel great distances in the body. They can be very easily dysregulated by trauma or compression.

Think of the nervous system as a living, sensitive, and vulnerable communications network that requires inordinate amounts of energy to function and maintain properly. It’s no wonder the nervous system is susceptible to injury, disease, metabolic abnormalities, immune problems, and many other ailments that can make it ill and fail.

Peripheral nervous system dysfunction is common, and when this occurs, people develop the cardinal symptoms of polyneuropathy.

Despite the fact that polyneuropathy is one of the most common peripheral nervous system disorders, there are few FDA-approved drugs to treat it. Many patients who try traditional prescription medications to relieve their neuropathy symptoms are disappointed with the results.

Too often, newer drugs in the research pipeline appear promising, but fail because of undesirable side effects. Research and data from failed drug development experiments can sometimes be applied to herbal medicine, where natural substances work in ways similar to artificial chemicals, but with less severe side effects. The scientific study of natural substances that can mimic man-made drugs is called pharmacognosy . When this knowledge is applied to the nervous system, we call it neuropharmacognosy . This can be translated as the theory of the pharmacology of natural substances that can influence the functioning of the nervous system. There are a number of natural substances that can mimic the pharmacology of drugs used to treat neuropathy. We’ve discussed them in other articles, but we’ll go through them together here.

Based on experimental data on nerve function and disease, a number of broad classes of chemicals have theoretical utility in alleviating symptoms of neuropathy.

When nerves get sick, it appears that increasing a chemical known as GABA can calm irritated and inflamed nerves and provide relief for people struggling with the symptoms of neuropathy. You can think of GABA as a brake pedal, slowing down the symptoms of neuropathy. There is research to suggest that the herbs valerian root and lemon balm may increase GABA, which applies the body’s natural brakes on nerve pain. Valerian root can block an enzyme known as GABA-T, which breaks down and neutralizes GABA in the nervous system. By blocking the breakdown of GABA, valerian root can prolong the braking effect of GABA on the nerve and slow down the symptoms of neuropathy. Lemon balm appears to enhance the effects of GABA in a slightly different way. Rather than blocking the breakdown of GABA, lemon balm can stimulate an enzyme called GAD, which is responsible for building GABA. The braking effect of GABA on the diseased nerve is thus supported by the increased production of this neurotransmitter

If GABA acts like the body’s brakes on an out-of-control nervous system, glutamate is the nerve’s accelerator. Studies suggest that injured nerves become hypersensitive because glutamate is released after the nervous system is irritated. This has the effect of sensitizing the nerve and contributing to the signs and symptoms of neuropathy. There are two potentially important herbs that can block the effects of glutamate on the nervous system in neuropathy. The first is theanine , a protein derived from green tea. Theanine is believed to act as a glutamate analogue. This means that theanine is processed by the body like glutamate, but lacks the nerve-stimulating effects of glutamate. Think of theanine as an empty sphere that has the net effect of reducing the effects of glutamate. The other herb that can reduce the excitatory effects of glutamate is magnolia bark. Magnolia bark is believed to bind to and block a specific glutamate receptor. This suggests that magnolia bark is a specific antagonist of glutamate and may be a more specific way to take your foot off the accelerator in nerves damaged by neuropathy.

Consistent with our auto-analogy, if GABA is the nerve brake in neuropathy and glutamate acts like the gas pedal, a third chemical known as glycine could be considered the transmission. Glycine slows down the nervous system. Remember to put the nerve in low gear. Glycine downshifts the nerve directly in neuropathy, thus slowing and inhibiting the painful transmission of nerve signals, but it can also compete indirectly with glutamate. The mechanism by which glycine might provide relief to patients suffering from neuropathy is a little less straightforward. If a patient took a large dose of glycine, the nerves would slow down. However, this effect would not last long, since glycine is transported away from the nerve in the nervous system by a so-called glycine transporter. The glycine transporter has the net effect of getting rid of glycine, which effectively gets the nervous system back into high gear. This glycine transporter system is so effective that it makes glycine impractical as a treatment for neuropathy. Because of the glycine transporter, the nerve simply cannot keep enough glycine in the nerve to meaningfully slow down the function of a hypersensitive nerve. However, there are substances that can inhibit the glycine transporter , and this appears to be a promising avenue to improve the suppression of nerve hyperexcitability as seen in neuropathy. The herb prickly ash bark appears to be a major glycine transporter inhibitor. Prickly Ash has long been used to relieve pain. Likewise, the naturally occurring compound sarcosine is a known inhibitor of the glycine transporter. Both of these naturally occurring substances appear to be candidates for relieving the signs and symptoms of neuropathy.

Another avenue that can be used to alleviate neuropathy is through the endogenous cannabinoid receptor system. This system is activated by marijuana and is thought to suppress pain at the higher levels of the nervous system. The receptors of the endogenous cannabinoid system can be activated by certain breakdown products of fatty acids in the nervous system for pain relief without inducing the “high” and side effects associated with marijuana drug use . Substances that block the enzyme fatty acid amide hydrolase, or FAAH, appear to activate the endogenous cannabinoid system and are currently being studied for the treatment of neuropathic pain. There appear to be naturally occurring FAAH inhibitors in red clover and the herb MACA. This suggests that through their potential to modulate the activity of the enzyme FAAH, these herbs may be able to activate the endogenous cannabinoid system and relieve neuropathic pain.

Finally, with particular reference to the neuropathy associated with diabetes, the protein kinase – C or PKC enzyme and its relationship to T-type calcium channels may be therapeutic targets. It appears that elevated blood sugar unregulates PKC in diabetic nerves. PKC appears to drive specific calcium channels in diabetic nerves known as T-type calcium channels. These changes are thought to drive hypersensitivity and excitability, at least in nerves affected by diabetic neuropathy.

chelidonium Majus is an herbal remedy that can modulate PKC. The alkaloid chelerythrine found in this herb is a potent protein kinase C antagonist. This suggests a potential benefit of this herb in polyneuropathy . While it is generally safe, some reports of liver toxicity have been linked to chelidonium Majus appear in the medical literature.

Picrorhiza Kurroa is an herb that contains phytochemicals apocynin . At least one study suggests that apocynin prevents or significantly reduces the upregulation of Cav3.1 and Cav3.2 T-type calcium channels. This suggests that Picrorhiza Kurroa may be able to downregulate the overexpression of Cav3.2 T-type calcium channels, which are thought to contribute to nerve hyperexcitability seen in diabetic neuropathy.

A final note and warning about using internet information to treat a medical problem. Do not do it! The use of this article is intended solely for patients to discuss the information contained with their licensed healthcare provider. While herbal treatments are generally safe, they can have unwanted or unpredictable side effects. Only a licensed physician who is familiar with your specific medical condition can diagnose you with certainty and advise you on the treatment of your particular condition. Always consult and inform your doctor before adding or changing your treatment regimen.

dr Kukurin is a board certified chiropractic neurologist with a certification in acupuncture. He has over 25 years of experience treating neurological disorders using alternative medicine techniques. He has presented the results of his methods at conferences in Johns Hopkins. His patients’ findings have been published in journals listed in the National Library of Medicine. dr Kukurin has postgraduate medical training from Harvard Medical School, Johns Hopkins, the Mayo Clinic and the Russian People’s Friendship Medical School. dr Kukurin completed a nine-month postgraduate course in Advanced Practice at the National University of Health Sciences. The course covered the pharmacology of commonly prescribed drugs, pharmacognosy, which is the study of the pharmacology of natural substances, herbal medicine and toxicology. For more information about the conditions he treats, these treatments , and the results his patients have achieved, visit his website.

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How to Choose a Moisture Analyzer

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You’ll want to consider the following criteria when choosing a moisture analyzer:

  • Resolution (also termed readability or readout)
  • Repeatability
  • Characteristics of the product being analyzed
  • Features important to performing moisture analysis for product
  • Specialized capabilities

Chances are you experience “humidity” on hot summer days beyond high humidity. Examples include mushy potato chips (too much) and crumbly brownie cookies (too little). The moisture content plays a decisive role in almost all areas of life. That’s why researchers, QC, and government agencies rely on moisture analyzers to ensure products meet manufacturing moisture content and shelf-life specifications. This post gives you some useful buying tips for moisture meters.

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Chances are you experience “humidity” on hot summer days beyond high humidity. Examples include mushy potato chips (too much) and crumbly brownie cookies (too little). The moisture content plays a decisive role in almost all areas of life. That’s why researchers, QC, and government agencies rely on moisture analyzers to ensure products meet manufacturing moisture content and shelf-life specifications. In this article, you will get useful buying tips for Moisture Analyzers.

Why Purchase a Moisture Analyzer?

“A safe humidity level is a humidity level that is low enough to prevent the growth of undesirable microorganisms in the final product under the intended conditions of manufacture, storage, and distribution.” as per Title 21 of the Code of Federal Regulations Section n. The Code goes on:

“The maximum safe humidity level for footless water activity (aw). An aw is considered food safe when there is appropriate data showing that the food does not support the growth of undesirable microorganisms at or below the stated aw.”

While Title 21 of the CFR relates to food, moisture content also relates to other everyday issues. Examples are plastic resins, wood pellets, and sludge dewatering.

Details on Key Considerations to Purchase a Moisture Analyzer

If you are planning to buy a moisture meter and are feeling constrained by the wide range of choices, these tips for choosing a moisture meter should help you.

Moisture balance selection criteria are based on factors such as:

Resolution or the smallest difference that can be read on the display. This is also referred to as readability or readability.

Repeatability – the ability of a moisture analyzer to return the same result when the same sample is tested repeatedly. Expressed as standard deviation.

Functions that are important for performing moisture analysis. These are based on the properties of the product to be analyzed, e.g. B. those that require special heating profiles.

Specialized features such as testing products with extremely low moisture content specifications, providing graphical displays of changing moisture content, and creating libraries of commonly performed tests.

Moisture Analyzer Performance Functions

While Title 21 refers to “water activity” (aw), for the subject of this post, moisture is anything that evaporates on heating.  Examples include fats, oils, alcohol, and s, and solvents.

Moreover, moisture can lurk in places many folks would not suspect.  Three examples of where moisture can exist include:

On the surface of a sample.  This can be defined as bulk water attracted to other substances. Even though you might not see it, it can be there and its presence affects the weight of the substance. Surface moisture is most easily removed in a moisture analyzer.

In pores or capillaries, where it is more diffs difficult to remove.  Absorbed moisture can be inside the substance particle (think wet soil) or in tiny capillaries or crevices of roughly-shaped substances.    Generally evaporating this type of moisture takes more time than required to remove surface moisture.

Water molecules are chemically bonded with other molecules as water of crystallization or as hydrates or adhesively bound water chemically bonded to a material at the molecular level.

An example is gypsum. Evaporating water of crystallization is more complex than the surface and absorbed moisture because the substance may also have surface moisture as well as chemically bonded water.

Removing surface moisture is one part of the process; removing water of crystallization is another and more difficult part.  This is because the heat required may in some instances result in product decomposition.

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5 Smarter Ways to Grow Your Business in 2023

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Every year, there are fresh chances to grow your company. However, if you want to get the most out of them, you must be as aggressive as you can, which calls for coming up with new tactics and investing more effort than ever before in them. Here are five smarter ways to grow your business in 2023:

1. Create More Content

By using content marketing, you can expand your business and establish yourself as an industry thought leader. However, it’s also one of the most tedious and time-consuming tasks out there. 

And when you get down to it, your goal is not simply to create more content; it’s to grow your brand and increase revenue—which means making sure that all of this content is having an impact on your bottom line.

Although I think it’s important for businesses to update their content calendars frequently, this doesn’t mean you should stop creating new articles, videos, or podcasts. 

Instead, spend some time figuring out how each piece will bring in new customers and lead people back into the sales funnel so they become repeat customers over time instead of just one-time visitors who never return again after reading an article or watching an episode of your web series about best practises for running a small business (or whatever else might happen if someone finds themselves engaged with something related to what we do).

2. Create a Referral Program

Referral programmes are a great way to attract new clients, but they can also be used to increase the number of personal recommendations.

You can use referral programmes to increase your social media or email subscriber numbers.

3. Focus on Your Email List

Email list building can be a daunting task for business owners, but it’s also one of the most important things you can do to grow your business. 

If you don’t already have an email list and want to start one, we recommend this free guide by MailChimp: How To Build An Email List. 

Here are some other tips on how to build an email list:

  • Create an opt-in form that collects visitor information when they subscribe.
  • Offer exclusive content through emails.
  • Make sure your website is mobile responsive so people can easily sign up on their phones.
  • Use tools like LeadPages or OptinMonster to make it easy for visitors to subscribe (and make sure they receive confirmation).
  • Create special offers or coupons exclusively available through email subscriptions.
  • Use pop-ups that appear after visitors leave the site but before leaving the browser window; this will give them another chance (and hopefully get them signed up).

Remember, these are just some resources—there are many more online!

4. Create an Irresistible Offer

Offering a discount or bonus can be a great way to draw in new clients, but it’s crucial to avoid repeating the same promotion. If you’re struggling to come up with an irresistible offer for your business, then you might want to consider hiring a business coach to help you. A good business coach can also discuss your marketing, sales and pricing strategies.

If you want your customer base to grow, create unique offers for each market segment and target audience. For example:

  • Offer a free consultation before they buy anything from you.
  • Offer them a guarantee on their purchase (and make sure it actually works!).
  • Offer them help with the paperwork if they need it when making their purchase (this will show them how much more valuable your service is than others).

5. Deliver Exceptional Service

Being approachable to customers’ needs and going above and beyond to resolve their issues are essential components of exceptional customer service. Make your customers feel good about doing business with you, and they will come back for more.

These tips will help your business grow in 2023.

If you want to grow your business like a weed in 2023, there are five things you can do.

  • Create more content
  • Create a referral program
  • Focus on your email list
  • Create an irresistible offer
  • Deliver exceptional service

Conclusion

These five tips are just the beginning. To grow your business, you need to think creatively about how you can serve your customers better and be more responsive to their needs. And in the end, what’s the best way to do that? By listening! So make sure that you stay tuned-in to what they want and need—and give them what they want and need—and your business will flourish.

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How to Use BrickSeek to Compare Prices at Big-Name Stores

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Smart consumers are aware that doing a little bit of research, which is where BrickSeek comes in, may frequently mean the difference between obtaining a good deal and getting a genuinely slick deal. This internet site uses product identification numbers to locate the most affordable deals in your location on the items you want. Additionally, it displays product availability and provides information about the majority of significant big-box stores and merchants, including Amazon, Target, Walmart, and Staples.

Explain Brickseek.

BrickSeek was initially created to assist LEGO fans in finding difficult-to-find parts, but it has now expanded to include inventory data on nearly every product you can imagine. Using BrickSeek, you may check the availability of the items you’re looking for from well-known retailers like Target, Macy’s, Best Buy, and CVS.

BRICKSEEK IS A FANTASTIC TOOL FOR:

Find elusive objects

Keep track of hot deals

Prices for expensive items like televisions, PlayStations, Android phones, and other items can be compared.

Even clothing merchants and department stores like Macy’s and Kohl’s have a respectable online presence.

How Do I Use BrickSeek?

  1. Visit the BrickSeek Website

First, head to the BrickSeek website. You can search for a specific product or browse the current deals on the Home page.

Check out the links below to quickly browse the inventory at your favorite store:

Amazon Inventory tracker

Macy’s inventory tracker

Home Depot inventory tracker

Office Depot inventory tracker

Target inventory tracker

Walmart inventory tracker

Lowe’s inventory tracker

Best Buy inventory tracker

  1. Add the product details.

Enter the details for the item you are looking for next.

You need as many of the following details as you can about the product in order to achieve the best results:

SKU Number

UPC number

Model number

  1. See Which Stores Have Your Item In Stock.

Brickseek’s stock checker displays the prices at all the locations in your vicinity after you enter the item details. An inventory checker is a priceless tool if you frequently refresh stock pages and make extra trips to Walmart or Target to check on the PS5 refill status.

Of course, not everyone will be prepared with all of the information BrickSeek needs. Unreliable local retailers, clearance items, and inaccurate counts could all contribute to uneven data. Before the servers can catch up, a single viral Tweet or unique voucher might cause GameStop’s PlayStation inventory to crash. Fortunately, if Brickseek indicates that your desired item is out of stock, a quick trip to the in-store sale section might work in your favor.

Finding the SKU Number

We’re here to aid you to get the information you require to acquire discounts on the goods you desire! As an illustration, we’ll look up as much information as we can about a 50″ Samsung 4K UHD Smart LED TV at neighboring Walmart locations.

Here’s how to locate an item’s SKU number using Walmart as an example.

Find the item first on the Walmart website.

On the product URL, click. Near the finish, a six- to ean eight-digit string of numbers will be visible. Your SKU number is that.

Finding a DPCI Number

Not all retailers employ SKUs. A DPCI system is used by several shops, like Target, to track inventories.

The steps listed below can be used to determine an item’s DPCI number:

Look up the item you want on the retailer’s website.

Press CTRL+F (or Command+F on a Mac) to search for “DPCI” on the product page.

to view the item information, scroll down the page.

How to Find UPC Code

It can be a little more difficult to obtain the UPC, but you can manage it. We’ll utilise Walmart as an example website once more.

Visit A Product Page On The Walmart Website.

Press CTRL+U (or Command + Option + U if you’re a Mac user) to open the HTML source code from the item’s page.

To access the word finder, press CTRL+F (or Command +F on a Mac).

Do A Search For “UPC”

Once you locate the genuine UPC number, press next on the finder. As the first lengthier string of numbers follows the letters “UPC,” it will be simple to identify.

Where To Look For A Model Number

You may find the model number for the item in your wish list in a few different ways:

Older TVs: By flipping an older television over and looking at the back, you may quickly find the model number. There should be printing of the model.

On more recent SmartTVs, you often have the option to select “Support” and then “Contact Manufacturer” from the main menu. That will take you to a screen with all the necessary information.

We do not, however, have access to a physical television in our situation. If we already had one, we wouldn’t be looking to replace it. The model number is typically included in online listings straight on the product website page:

Do another CTRL+F (or Command for Mac) search for the word “model” on the page. The model number should be quite simple to locate.

Finally, you can use the Brickseek search bar to hunt for things by entering terms like “speakers,” “headphones,” or “iPad.” The desired item can then be found by scrolling through the results.

Useful Hints For Brickseek

You are now prepared to use BrickSeek because you have all the necessary information. BrickSeek provides you a solid sense of which retailers in your neighborhood have the items you’re looking for in stock once you’ve entered all the necessary identifiers. Additionally, it offers details on costs and even an estimate of the quantity of the item that each retailer has in stock.

To get the best results, just keep in mind to be as detailed as you can within the search parameters.

Slickdeals Tip: It’s also worthwhile to check out different zip codes in your neighborhood because Brickseek might find more hidden inventory and clearance sales at nearby retailers. You have a better chance of finding what you’re looking for if there are more stores. Before you go shopping, don’t forget to hunt for coupons and free delivery offers.

Check out BrickSeek’s Deals page for even more deeply discounted products from stores and online merchants like Target, Amazon, Home Depot, and others.

BrickSeek: Is It Authentic?

BrickSeek is a reliable resource for locating sales at various merchants and checking inventories for items that are running low. Though BrickSeek is a helpful tool, keep in mind that it is not perfect. The information may be outdated because the service has no direct affiliation with any of the main retailers.

BrickSeek constantly informs users that the website is NOT meant to be used as a tool for price matching and that there can be differences between BrickSeek’s data and the actual inventory of the business. Would the delight of a great purchase taste as sweet if there was a Home Depot or Walmart inventory checker?

Nevertheless, it’s a reliable method for building an inventory research foundation when you begin looking for something new. You can shop more wisely if you have a basic understanding of Target’s resupply plan and Walmart’s tendencies for clearance sales. Just be careful not to rely too heavily on it during big deals like Black Friday because stock might change at any

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