Neuropathy literally means diseased nerves. There are a number of different reasons why people develop neuropathy. Neuropathy is quite commonly associated with diabetes, vitamin deficiencies, nerve inflammation, and toxins that poison the nerves. We have discussed many of the conditions that cause nerve disease in patients in other articles. Patients suffering from the signs and symptoms of neuropathy experience pain, burning, numbness, and other strange sensations known as paresthesias, which usually start in the feet and spread to the rest of the body. Regardless of the cause of the neuropathy, the pain and other symptoms can be debilitating and incapacitating.
The nervous system in higher animals like humans is a highly complex collection of specialized cells known as neurons. Neurons have several unique features, including a wire-like extension known as an axon. The axon works much like an electrical wire, carrying coded electrical signals known as nerve impulses throughout the body. Just like a copper wire, the nerve axon has an insulation known as myelin. Unlike a copper wire, a nerve cell and its wire-like axon are living tissue. The neuron contains all of the cellular machinery necessary to produce energy, sustain itself, and generate energy to support its function of sending and receiving electrical signals. Blüten kaufen Each neuron is an electrochemical marvel and essentially a living battery. This amazing communication network occurs at the microscopic level and consumes incredible amounts of energy to function properly.
The myelin insulation that surrounds the nerve axon is also a living tissue, and the nerve cell and its myelin cell partners are closely arranged to sustain and support each other.
The nervous system typically does a remarkable job of sending and receiving information from different parts of the body, acting both as a sensory system to monitor what’s going on in the body and as an effector system, driving necessary changes in the body based on the input from the sensors.
Because of its complexity, the nervous system and its supporting myelin cells are vulnerable to the slightest perturbation of metabolism. The axons are like a microscopic spider web, yet they travel great distances in the body. They can be very easily dysregulated by trauma or compression.
Think of the nervous system as a living, sensitive, and vulnerable communications network that requires inordinate amounts of energy to function and maintain properly. It’s no wonder the nervous system is susceptible to injury, disease, metabolic abnormalities, immune problems, and many other ailments that can make it ill and fail.
Peripheral nervous system dysfunction is common, and when this occurs, people develop the cardinal symptoms of polyneuropathy.
Despite the fact that polyneuropathy is one of the most common peripheral nervous system disorders, there are few FDA-approved drugs to treat it. Many patients who try traditional prescription medications to relieve their neuropathy symptoms are disappointed with the results.
Too often, newer drugs in the research pipeline appear promising, but fail because of undesirable side effects. Research and data from failed drug development experiments can sometimes be applied to herbal medicine, where natural substances work in ways similar to artificial chemicals, but with less severe side effects. The scientific study of natural substances that can mimic man-made drugs is called pharmacognosy . When this knowledge is applied to the nervous system, we call it neuropharmacognosy . This can be translated as the theory of the pharmacology of natural substances that can influence the functioning of the nervous system. There are a number of natural substances that can mimic the pharmacology of drugs used to treat neuropathy. We’ve discussed them in other articles, but we’ll go through them together here.
Based on experimental data on nerve function and disease, a number of broad classes of chemicals have theoretical utility in alleviating symptoms of neuropathy.
When nerves get sick, it appears that increasing a chemical known as GABA can calm irritated and inflamed nerves and provide relief for people struggling with the symptoms of neuropathy. You can think of GABA as a brake pedal, slowing down the symptoms of neuropathy. There is research to suggest that the herbs valerian root and lemon balm may increase GABA, which applies the body’s natural brakes on nerve pain. Valerian root can block an enzyme known as GABA-T, which breaks down and neutralizes GABA in the nervous system. By blocking the breakdown of GABA, valerian root can prolong the braking effect of GABA on the nerve and slow down the symptoms of neuropathy. Lemon balm appears to enhance the effects of GABA in a slightly different way. Rather than blocking the breakdown of GABA, lemon balm can stimulate an enzyme called GAD, which is responsible for building GABA. The braking effect of GABA on the diseased nerve is thus supported by the increased production of this neurotransmitter
If GABA acts like the body’s brakes on an out-of-control nervous system, glutamate is the nerve’s accelerator. Studies suggest that injured nerves become hypersensitive because glutamate is released after the nervous system is irritated. This has the effect of sensitizing the nerve and contributing to the signs and symptoms of neuropathy. There are two potentially important herbs that can block the effects of glutamate on the nervous system in neuropathy. The first is theanine , a protein derived from green tea. Theanine is believed to act as a glutamate analogue. This means that theanine is processed by the body like glutamate, but lacks the nerve-stimulating effects of glutamate. Think of theanine as an empty sphere that has the net effect of reducing the effects of glutamate. The other herb that can reduce the excitatory effects of glutamate is magnolia bark. Magnolia bark is believed to bind to and block a specific glutamate receptor. This suggests that magnolia bark is a specific antagonist of glutamate and may be a more specific way to take your foot off the accelerator in nerves damaged by neuropathy.
Consistent with our auto-analogy, if GABA is the nerve brake in neuropathy and glutamate acts like the gas pedal, a third chemical known as glycine could be considered the transmission. Glycine slows down the nervous system. Remember to put the nerve in low gear. Glycine downshifts the nerve directly in neuropathy, thus slowing and inhibiting the painful transmission of nerve signals, but it can also compete indirectly with glutamate. The mechanism by which glycine might provide relief to patients suffering from neuropathy is a little less straightforward. If a patient took a large dose of glycine, the nerves would slow down. However, this effect would not last long, since glycine is transported away from the nerve in the nervous system by a so-called glycine transporter. The glycine transporter has the net effect of getting rid of glycine, which effectively gets the nervous system back into high gear. This glycine transporter system is so effective that it makes glycine impractical as a treatment for neuropathy. Because of the glycine transporter, the nerve simply cannot keep enough glycine in the nerve to meaningfully slow down the function of a hypersensitive nerve. However, there are substances that can inhibit the glycine transporter , and this appears to be a promising avenue to improve the suppression of nerve hyperexcitability as seen in neuropathy. The herb prickly ash bark appears to be a major glycine transporter inhibitor. Prickly Ash has long been used to relieve pain. Likewise, the naturally occurring compound sarcosine is a known inhibitor of the glycine transporter. Both of these naturally occurring substances appear to be candidates for relieving the signs and symptoms of neuropathy.
Another avenue that can be used to alleviate neuropathy is through the endogenous cannabinoid receptor system. This system is activated by marijuana and is thought to suppress pain at the higher levels of the nervous system. The receptors of the endogenous cannabinoid system can be activated by certain breakdown products of fatty acids in the nervous system for pain relief without inducing the “high” and side effects associated with marijuana drug use . Substances that block the enzyme fatty acid amide hydrolase, or FAAH, appear to activate the endogenous cannabinoid system and are currently being studied for the treatment of neuropathic pain. There appear to be naturally occurring FAAH inhibitors in red clover and the herb MACA. This suggests that through their potential to modulate the activity of the enzyme FAAH, these herbs may be able to activate the endogenous cannabinoid system and relieve neuropathic pain.
Finally, with particular reference to the neuropathy associated with diabetes, the protein kinase – C or PKC enzyme and its relationship to T-type calcium channels may be therapeutic targets. It appears that elevated blood sugar unregulates PKC in diabetic nerves. PKC appears to drive specific calcium channels in diabetic nerves known as T-type calcium channels. These changes are thought to drive hypersensitivity and excitability, at least in nerves affected by diabetic neuropathy.
chelidonium Majus is an herbal remedy that can modulate PKC. The alkaloid chelerythrine found in this herb is a potent protein kinase C antagonist. This suggests a potential benefit of this herb in polyneuropathy . While it is generally safe, some reports of liver toxicity have been linked to chelidonium Majus appear in the medical literature.
Picrorhiza Kurroa is an herb that contains phytochemicals apocynin . At least one study suggests that apocynin prevents or significantly reduces the upregulation of Cav3.1 and Cav3.2 T-type calcium channels. This suggests that Picrorhiza Kurroa may be able to downregulate the overexpression of Cav3.2 T-type calcium channels, which are thought to contribute to nerve hyperexcitability seen in diabetic neuropathy.
A final note and warning about using internet information to treat a medical problem. Do not do it! The use of this article is intended solely for patients to discuss the information contained with their licensed healthcare provider. While herbal treatments are generally safe, they can have unwanted or unpredictable side effects. Only a licensed physician who is familiar with your specific medical condition can diagnose you with certainty and advise you on the treatment of your particular condition. Always consult and inform your doctor before adding or changing your treatment regimen.
dr Kukurin is a board certified chiropractic neurologist with a certification in acupuncture. He has over 25 years of experience treating neurological disorders using alternative medicine techniques. He has presented the results of his methods at conferences in Johns Hopkins. His patients’ findings have been published in journals listed in the National Library of Medicine. dr Kukurin has postgraduate medical training from Harvard Medical School, Johns Hopkins, the Mayo Clinic and the Russian People’s Friendship Medical School. dr Kukurin completed a nine-month postgraduate course in Advanced Practice at the National University of Health Sciences. The course covered the pharmacology of commonly prescribed drugs, pharmacognosy, which is the study of the pharmacology of natural substances, herbal medicine and toxicology. For more information about the conditions he treats, these treatments , and the results his patients have achieved, visit his website.
What Display Material Is Best for Your Small Business?
Whether it’s for your grand opening, a brand event or your storefront, display material is a great way to convey a message to the public and attract potential customers. Given the vast choice available to you, however, finding the type of display that best suits your objectives requires some thought. To help you find your way around, here is an overview of the possibilities that might interest you.
Panels with a foam core are light and easy to transport since they are made of a material that resembles that found in expanded polystyrene foam (Styrofoam). These signs have an extra layer of thickness compared to simple paper posters. With their sturdy foam backing, they are ideal for signage, presentations, and commercial and event materials. Their exterior is covered with matte paper that adds style to your message. It can be a cheap solution to showcase your visual concept without having to frame it. However, foam panels resist damage poorly and can easily be punctured. And since they are not waterproof, it is best to limit their use indoors.
Coroplast is the registered brand name for corrugated plastic sheets. This material features a waterproof and durable plastic coating that lends itself well to displays placed outside to attract the public. In addition, it has a glossier finish than foam panels. Most exterior signs are made of this weather-resistant and relatively inexpensive material, making it a good choice if you need a large number of copies.
Polyvinyl chloride (PVC) panels are rigid, durable, lightweight, and waterproof – all characteristics that lend themselves well to outdoor use. This type of display has a smoother matte finish, ideal for highlighting, on one or both sides, a premium color visual. Due to its composition, it is not as prone to damage as foam panels, which helps to maintain its quality once outdoors.
Portable and reusable, banners can be transported almost everywhere: busy places, special events, and trade shows. Plus, they can be reused over and over again, which is appreciated by most small business owners who don’t want to keep buying new advertising material. The plastic contained in the vinyl ensures durability against wear and weather. Since vinyl is not a rigid material, the banners must however be fixed to a support or provided with eyelets that can receive a rope or a cable. And just like fabric, they can be hemmed for a neater effect.
Posters are a great visual aid that can help raise awareness for small businesses wherever they are displayed. They are particularly interested in a shop window, where they inform passers-by of events taking place in the store. They are usually printed on matte or glossy paper in virtually any size, and for less than other products. Most are intended for single use.
Explore more display options at The UPS Store
Incorporating display into your advertising strategy is an affordable and customizable way to promote the products and services offered by your small business. You can have all of the above displays custom printed at a UPS Store location. Feel free to call us to learn more about our professional printing services, or visit our online printing portal to browse, create or download the model of your choice and opt for one of the products from our range. specially designed to meet your needs. Otherwise, drop by a center near you!
Get $5,000 Personal Loans with Guaranteed Approval – No Issues of Bad Credit!
Have a bad credit score and are worried about not getting a personal loan? Now, you just don’t have to worry as you can easily get a personal loan of up to $5,000 even with bad credit.
Loans make life easier and happier when you don’t have access to money on an immediate basis. For example, an emergency can occur at any point. Therefore, a personal loan with guaranteed approval does the job like a charm.
If you have a poor history of a bad credit score and you need money to cover important expenses, then there are a few online lenders that would help you out! However, banks usually disapprove of such applications. So, online lenders are the way to go!
Here we’ll explain how to get a $5,000 personal loan with instant approval and no credit check:
Is it possible to get a $5,000 personal loan along with a bad credit score?
In today’s world, everything is possible. Nonetheless, you just have to knock on the right door! A credit score is considered to be an extremely important indicator in making you worthy enough to get a personal loan immediately. For banks, a bad credit score is a clear RED ZONE!
If you contact us, we’ll definitely look forward to helping you out and providing the necessary monetary help despite a bad credit score. We have our own tailor-made process of approving loans that also includes applications with bad credit history. If you’re impressed, let me highlight how we work:
We provide instant approval for personal loans and hassle-free service so that you’re able to achieve your goals.
There’s a bad credit personal loans guaranteed approval $5,000 for everyone. For us, every customer is just the same.
As you fill-up the application, we’ll immediately start the rest of the process. Also, there are no hidden fees to misguide our precious customers.
The process is extremely simple with little to no paperwork. Moreover, we’ll reach out to you within 24 hours.
How to get a $5,000 personal loan on an immediate basis with bad credit?
The process is pretty straightforward and basic. Let me guide you about the steps:
- Go to our website and find the application form.
- Fill out the application form according to the mentioned criteria.
- Finally, approve the mentioned terms & conditions after reading them.
- Now, just simply apply for the loan.
Also, don’t forget to mention other details like your current employment status, bank details, and personal information.
Then, submit the application right away. As soon as we receive the application, we start the further process swiftly.
Guaranteed $5,000 Personal Loan Approval with Bad Credit Score: Summing Up
Did you just see how easy it was to get a guaranteed personal loan of $5,000 even when you’ve got a bad credit score? There’s no need to worry about any sort of expenses. Just fill out the application today and enjoy!
What Are the Best Bags for Taking Food to Work?
If you are one of those who eat at the office or have to eat at the study center where you go daily, surely you have asked yourself: What bag or lunch box do I choose to store my food containers?
We have made a selection of the best-selling food carrier bags on Amazon and the most outstanding bags to take food from the Fnac store. There are many types and models!
The split day in the workplace forces us, on many occasions, to have to take food to the workplace because we do not have time to go home to eat. The same happens with many university students who have classes in the morning and in the afternoon.
And since this routine can make us bored with all the Tupperware meals, we recommend that you choose quick and different Tupperware meals for each day of the week. Although the most common is to prepare pasta dishes or salads, there are many tapas dishes that you can take without problem (soups with foundation, stews, legumes in salads or stews.
On the other hand, it is also very important to have an organization of all the tapas menus to ensure a healthy, varied, and balanced diet.
And once the daily menu is ready, all we need is the bag to take lunch boxes to work or university. Below we show you a very varied list of the different food carrier bags that you can find both on Amazon and on Fnac. Choose the one that best suits you!
Amazon’s Best Lunch Bags
At Amazon, you can find multiple bags for food, but we will show you which ones are the best sellers and which ones we would choose to take to work daily. Take a look and choose the one that best fits into your day-to-day!
Tatay casual bag (with 4 airtight containers)
One of Amazon’s best-selling classic lunch bags is this Tatay brand casual lunch bag with a square shape and a gray checkerboard design. Its capacity is 3 liters, it measures 22.5cm x 10cm x 22cm, and includes 4 airtight containers (2 round containers of 0.2 liters and 2 oval containers of 0.5 liters).
This food carrier bag offers high thermal resistance thanks to its triple-layer insulating material and a piece of waterproof fabric that facilitates internal cleaning. In addition, it includes an internal pocket to place cutlery and napkins and an easy opening on both sides. Its price is very economical (only 18.09 euros with the four containers included).
It is an ideal bag to take to work thanks to its two handles (one to carry in your hand and the other to hang as a shoulder strap). This is the best-selling color and type of food carrier bag , but you can find a wide range of bags from this brand in different colors and sizes.
Roll & Go Tatay bag (with 2 airtight containers)
Another of Amazon’s best-selling takeout bags is this roll & go food carrier bag from the Tatay brand with a roll-up design that will allow you to fold it according to the number of containers you add each day. Its capacity is 4 liters, it measures 22 cm x 11 cm x 22.5 cm, and includes 2 airtight plastic containers of 0.5 liters.
This food carrier bag has a high thermal resistance thanks to its triple-layer insulating material and waterproof fabric that facilitates its internal cleaning. It includes two outer pockets to place fruit or cutlery and has a double closure system (velcro and buckle).
You can find it in two colors (blue and grey) and its price is very cheap (16.49 euros).
Maxtop food bag
This Maxtop food carrier bag is Amazon’s best-selling cooler bag thanks to its capacity and ease of transport. It is perfect for those who spend the whole day away from home and need to take lunch, dinner, snacks, and some other snacks with them. It has a size of 25.4cm x 17.8cm x 25.4cm and its capacity is 10 liters, so you can also use it to take drinks or food to the beach or on picnic getaways.
It includes an interior mesh pocket to place cutlery, an exterior pocket (to store a mobile phone, keys, wallet…), and two zippered mesh pockets for a drink or an umbrella. Thanks to its 5 mm thick insulating pearl foam it can keep food and drinks cold or keep them hot for up to 4 hours.
In addition, its strap is adjustable and removable so you can choose if you want to carry it as a shoulder bag or as a briefcase. Its price is 21.99 euros.
Tatay mini bag (with hermetic lid)
Another option for those who eat only one dish and want to take little bulk to work is to use this mini Tatay food carrier bag with a capacity of 1.5 liters. It measures 21.5cm x 9cm x 12cm and is made with a triple layer of a resistant material that makes it thermal and waterproof.
This food bag has an interior mesh pocket to store cutlery and includes a 0.5-liter oval plastic airtight container. It will be perfect to take to work and take up as little space as possible. You can get it for less than 12 euros.
Shell Tatay bag (with 2 airtight containers)
And another type of bag to carry Tupperware from the Tatay brand is this Shell bag with an opening on both sides and a capacity of 5.6 liters. Thanks to its rigid case (from Safecover), it will be safe and comfortable to carry all kinds of food without damaging it with knocks.
This food carrier bag has a high thermal and waterproof resistance thanks to its triple layer of insulating material and offers a padded handle to carry the bag hanging more comfortably. It includes 2 airtight containers of 0.75 liters each and its price is 26.10 euros.
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